Vascular Dementia and Neurodegenerative Diseases

Dr. Pant received his M.A. and Ph.D. degrees in Physics from Agra University, Agra, India. His postdoctoral studies were conducted on the mechanisms of electron and ion transport in model membrane systems at the Department of Biophysics at Michigan State University. He joined the Laboratory of Neurobiology in the NIMH as a senior staff fellow in 1974 with Dr. Ichiji Tasaki where he studied the function of the axonal cytoskeleton in the squid giant axon. In 1979 he moved to the NIAAA extending his studies on the neuronal cytoskeleton and the effects of alcohol on its regulation. Dr. Pant moved to the NINDS, Laboratory of Neurochemistry in 1987 where he is presently chief of the section on Cytoskeleton Regulation. His laboratory is studying the mechanisms of topographic regulation of neuronal cytoskeleton proteins by post-translational modification, including the role of kinase cascades in normal brain and during neurodegeneration

The major focus of this laboratory has been to study the mechanisms of topographic regulation of neuronal cytoskeletal proteins regulation by phosphorylation and neurodegeneration.

Si Ching Lim has a special interest in dementia care particularly in patients with behavioural and psychological symptoms of dementia. She is currently In-charge of a 20 bedded dementia ward in a teaching hospital in Singapore and is responsible in developing the ward and training the staff in managing elderly with delirium and dementia with challenging behaviour. She is also an Adjunct Assistant Professor at National University of Singapore and Dukes Graduate Medical School.

Dementia

Dr. Gjumrakch Aliev, MD, PhD, President “GALLY” International Biomedical Research Institute Inc., San Antonio, Texas, USA. He also hold appointment with the University of Atlanta, Atlanta, Georgia, USA as a Professor of Cardiovascular, Neuropathology, Gerontology, Health Science and Healthcare Administration, and as a Leading Scientist , Institute of Physiologically Active Compounds. Russian Academy of Sciences, Moscow Region, Chernogolovka, Russian Federation. He received his MD in 1982, from the Baku Medical University (former USSR) with cum laude. Then he accomplished his PhD in Cardiovascular Diseases from the prestigious Russian Academy of the Medical Sciences, Moscow, Russia in 1988 with cum laude. He received postdoctoral training with Professor G. Burnstock in the University College of the London. He authored and coauthored more than 500 publications in the fields of neurodegenerative diseases research (Alzheimer disease), as well as cardio- and cerebrovascular disease, cancer, and electron microscopy. He is an outstanding teacher, scholar, and a renowned scientist in the area of cellular molecular physiology, and cardiovascular, and neurodegeneration-mediated pathologies including Alzheimer disease (AD). He is nationally and internationally reputed in his area. Dr. Aliev’s accomplishments in the area of biochemistry and cellular biology have tremendous implications for drug design towards CNS Neurological Disorders, AD, cancer, and cerebrovascular and neurodegeneration related pathologies. He is world-renowned expert in electron microscopy. His work has been published in numerous prestigious journals such as New England journal of Medicine, Nature Clinical Cardiology, J. Neuroscience, Scientific Reports, Circulation Research, Blood, J. Cellular and Molecular Medicine, Atherosclerosis, CNS Neurological Disorders & Drug Targets, international J. Biochemistry and Cell Biology and many others which reflect his leading role in his research areas. He is currently the Editor in Chiefs for “Central Nervous System Agents in Medicinal Chemistry”, “Applied Cell Biology”, “World Journal of Neuroscience”, “Open Journal of Psychiatry”, “Journal of Aging Science”, “Cardiovascular & Hematological Agents in Medicinal Chemistry”, “Immunology, Endocrine and Metabolic Agent in Medicinal Chemistry” as well as which by itself shows the voluminous and outstanding work he has accomplished in the area of cellular and molecular biology as well as aged associated clinical sciences. He is one of most cited authors in his fields with high impact factors.

dEMENTIA, Parkinson's disease, strokes and other brain diseases,

Dr. Shu Chen received his Ph.D. in Biochemical Pharmacology from the State University of New York at Buffalo in 1993. He came to CWRU as a Research Associate and moved on to be an Instructor and Assistant Professor in Case's Institute of Pathology. Presently, Dr. Chen is an Associate Professor of Pathology (2002-) and an Associate Director of the National Prion Disease Pathology Surveillance Center (2003-).

Alzheimer's disease, Parkinson's disease and prion disease are neurodegenerative diseases characterized by neuronal cell death and accumulation of insoluble protein aggregates. Prion disease is unique in that it consists of a group of heterogeneous brain disorders affecting both humans (such as Creutzfeldt- Jakob disease, CJD) and animals (such as mad cow disease). In humans, prion disease can be sporadic, inherited, or acquired by infection. The hallmark of prion disease is the presence of an abnormal isoform of prion protein (PrP) in the diseased brain. It is thought that the abnormal PrP is derived from the normal PrP that is also expressed in brain and throughout the body.

Dr. Foundas completed her undergraduate studies at Wellesley College, and went on to graduate from Louisiana State University School of Medicine in New Orleans in 1986. Dr. Foundas completed her Neurology residency training at the University of Florida in Gainesville where she also trained with Dr. Kenneth M. Heilman as a Post-doctoral Research Fellow in Cognitive and Behavioral Neurology. Dr. Foundas came to New Orleans in 1992 as Assistant Professor of Neurology at Tulane University School of Medicine. She rapidly rose through the ranks to Professor of Neurology in 2003. Dr. Foundas served as the Director of Neurology Residency Training and Co-Director of the combined programs of Medicine-Neurology and Psychiatry-Neurology Residency Training from 1995 to 2008. Dr. Foundas was the Director of Medical Student Education in Neurology in 2007 to 2008.

Aging, Dementia, and Stroke

Hans von Holst received his Medical Doctor´s degree in 1976 at Karolinska Institutet and completed his specialist training in Neurosurgery 1982 at Karolinska University Hospital. In 1985 he earned his PhD when he also became Associate Professor in Neurosurgery, Clinical Neuroscience at Karolinska Institutet. Since 1988 he holds a position as Senior Physician in Neurosurgery at Karolinska University Hospital. During 1991-1996 he was appointed as Chairman of the Dept of Neurosurgery and Division Manager of the Neuroclinics at Karolinska University Hospital, respectively. From 1992 to 2006 he was appointed as chairman of the World Health Organization collaborating center for neurotrauma at Karolinska Institutet. Since 2003 he is Professor in Neuroengineering and Head of the Division of Neuroengineering at the Royal Institute of Technology in Stockholm. He has over 120 original research publications, book chapters and books.

Dementia,Vascular Dementia,Neurosurgery

Jerzy Leszek is a full time professor of psychiatry at the Medical University in Wroclaw , Poland ,vice –director of the Psychiatry Department and head of Alzheimer’s Disease Lab. He is author and co-author more than 210 papers (especially from old age psychiatry), some chapters to the books published in reputed Polish and international journals and serving as an editorial board member of several journals .He is Scientific Editor and co-author of first Polish academic handbook on Alzheimer’s disease and seven another academic handbooks from psychogeriatry , member a lot of scientific associations eg founder and president of Lower Silesian Association of Alzheimer’s Families, first of its kind in Poland and Former Member of Board of Directions of International Psychogeriatric Association and President of Polish Psychogeriatric Association.

Alzheimer’s disease Therapy of dementia disorders in the light of new technologies :nanotechnology, proteomics, metabolomics, genomic medicine, personalized therapy Molecular base of neurodegenerative disorders Rehabilitation and physical activity of dementia disorders

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Michael Entzeroth is currently Chief Scientific Officer/Chief Operating Officer of Cennerv Pharma (S) Pte Ltd in Singapore, a company focused on the development of novel drugs for the treatment of central nervous diseases. From 2007 to 2013, he was the Deputy Director and Vice President Research and Development and Deputy Director of the Experimental Therapeutic Centre, Biopolis, Singapore. Previously, he was Chief Scientific Officer of S*BIO Pte Ltd in Singapore and between 1999 and 2002, as Vice President of CEREP SA in France, he was a member of the Executive Management Committee. From 1985 to 1999, with Boehringer Ingelheim, Germany, he was responsible for a variety of drug discovery programs. A number of drug candidates, he worked on during his career, are either on the market or in advanced clinical stage. Over the years, results from his work have been published in more than 50 publications in peer-reviewed scientific journals.

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Dr. Goldsmith has been a professor of surgery for more than forty years and a student of medical history throughout his life. He wrote the book A Conspiracy of Silence: Franklin D. Roosevelt—Impact on History. He also invented several surgical procedures including an operation to control Alzheimer’s disease, a procedure to treat acute and chronic spinal cord injuries, as well as an operation to eliminate the need for a permanent colostomy. He is an author of 265 papers or book chapters, has edited four surgical texts, and has received honorary degrees from two Chinese universities. He is a surgeon, worldwide lecturer, and adviser on the application of his surgical procedures

Alzheimer’s disease

Dr. Federoff will oversee and guide the development of UC Irvine Health. In addition to leading the School of Medicine, he will provide strategic direction for the clinical programs of UC Irvine Medical Center and all affiliated patient care centers and will ensure the alignment of the clinical enterprise and the physicians’ practice plan with the university’s academic and research missions. He will also provide guidance on the development and integration of UCI’s health-related academic programs in nursing science, public health and pharmaceutical sciences.

pharmaceutical sciences, nursing science

David has worked in community based mental health services in the UK for over thirty years developing services for people with complex care needs and enduring mental health problems in a career spanning the voluntary sector, local authority services, and the NHS.. From 2009 - 2011 he was the Dementia Implementation Lead for Commissioning Support for London, working with commissioners across London to improve dementia services. He is an independent writer and researcher on dementia support and services for Black and minority ethnic communities, working with a number of projects and initiatives.

Dementia, Mental Health

Partner at a personal injury law firm specializing in T.B.I. The National Trial Lawyers “Top 100 Trial Lawyers”. BS Magna Cum Laude 1990 and Juris Doctorate 1993. Vice-Chairman of B.O.D. Mothers Against Drunk Driving National. & B.O.D. Brain Injury Alliance. 20x year keynote at National Brain Injury Conferences. All honorariums donated to charities. Authored Spring Break: A True Story of Hope and Determination regarding a brain injured college student who received long-term inpatient, outpatient care and rehabilitation. Awarded: US Senate Official Proclamation, US Congressional Citation, U.S. House of Representatives Special Congressional Recognition, 20+ awards for legal and charitable accomplishments.

Traumatic Brain Injury

Mootaz Salman is a pharmacist and researcher PhD student at the Biomolecular Sciences Research Centre (BMRC) at Sheffield Hallam University, working with Prof. Nicola Woodroofe and Dr. Matthew Conner’s research group and a member of the multi-institute Aquaporin research collaboration. His research interest focus on the identification of new drug targets for brain oedema and epilepsy through his work on the special water channels called “Aquaporins”. Mootaz graduated with Outstanding Distinction in his MSc winning the Sheffield Hallam University prize for the most scientific contribution and ranked 1st in year. His PhD research requires the skilled use of numerous techniques ranging from standard biochemical and molecular biology to cutting edge micro-array and laser confocal microscopy. Mootaz is an international ambassador at Sheffield Hallam University, ambassador for British Society of Experimental Biology (SEB); and STEM ambassador since 2014. He has given four invited oral presentations and talks at major international conferences in Canada, Netherlands, Romania and Japan along with three talks at a national level. He is also an active member in a number of scientific societies nationally and internationally including USA, Canada and Japan. He has been selected to be an abstract reviewer at two major international conferences; Brain 2015 in Canada and also for the upcoming Brain 2017 in Berlin, along with being an abstract reviewer and a member of poster judgement panel during the North of England Postgraduate Conference (NEPG) which is the UK's largest annual postgraduate conference for medical biosciences. Mootaz has successfully participated in organising a number of national and international high profile conferences and also he has been selected to chair scientific sessions at two national events.

Molecular Pharmacology, Neurochemistry, Astrocytes and Cerebral Aquaporins

Dr. Federoff will oversee and guide the development of UC Irvine Health. In addition to leading the School of Medicine, he will provide strategic direction for the clinical programs of UC Irvine Medical Center and all affiliated patient care centers and will ensure the alignment of the clinical enterprise and the physicians’ practice plan with the university’s academic and research missions. He will also provide guidance on the development and integration of UCI’s health-related academic programs in nursing science, public health and pharmaceutical sciences.

pharmaceutical sciences, nursing science

Jane Verity is the Founder of Spark of Life and CEO of Dementia Care Australia. Jane is a world leader and pioneer in the social and emotional care of people with dementia. Originally from Denmark and now living in Melbourne, Australia, Jane is an Occupational and Family Therapist and a Master Practitioner in NLP. She has earned the highest international accreditation as a professional speaker and is known for her life changing presentations. Jane has authored 2 internationally published books and contributed to others. She is also a regular contributor to journals and an international key note presenter.

social and emotional care of people with dementia

Post TBI patients comprehensive care for headaches and cognitive rehab, neck pain and back pain. Neuro cognitive evaluation, treatment and rehabilitation for early recovery. Dr Kumar provides forced oxygen therapy for acute and sub acute concussion/ mild traumatic brain injury and treatment of other neurological disorder routinely in his office. Comprehensive Traumatic Brain Injury Center 1. Screening for our football/basketball players/contact sports for concussion head injury 2. Immediate forced oxygen therapy for Mild TBI patients. 3. Treatment and control of physical symptoms of the MTBI 4. 1 hour EEG and MRI brain DTI test for MTBI evaluations 5. Neurocognitive testing and neuro behavioral testing with in first week of the MTBI to plan neurocognitive therapy or neuro-rehabilitation 6. Visio-spatial/Speech/ occupational/ Computer based neurocognitive therapy 7. Early recovery from MTBI with providing other support systems. Urgent Headaches Clinic 1. We treat Walk-in headache patients 2. Iv infusion and Oxygen therapy for headaches 3. Nerve blocks and Botox therapy for headaches Neurology Clinic 1. Non Narcotics treatment of headaches, neck pain, upper & lower back pain 2. Peripheral neuropathy or limb pain 3. Seizure disorder 4. Dementia 5. Post stroke therapy or other neurological disorder Gene Based Medication Therapy 1. All Our patients are enrolled in gene based medication therapy. Genetics based medication therapy to ensure the medication efficacy and decrease side effect for headaches and seizures disorders. 2. We have joined hand with John Hopkins in research study to provide gene based medication therapy. Neurology Research Center 1. Active research site for multi-center research trial 2. Active research site for our own services. 3. Publishing research to contribute and create knowledge

Neurology, Cognitive science

Molecular biologist interesting in iron metabolism and 5'UTR based RNA therapeutics for helping individuals suffering from neurodegenerative diseases.

Molecular biology, neurology

David has worked in community based mental health services in the UK for over thirty years developing services for people with complex care needs and enduring mental health problems in a career spanning the voluntary sector, local authority services, and the NHS.. From 2009 - 2011 he was the Dementia Implementation Lead for Commissioning Support for London, working with commissioners across London to improve dementia services. He is an independent writer and researcher on dementia support and services for Black and minority ethnic communities, working with a number of projects and initiatives.

Dementia, Mental Health

Partner at a personal injury law firm specializing in T.B.I. The National Trial Lawyers “Top 100 Trial Lawyers”. BS Magna Cum Laude 1990 and Juris Doctorate 1993. Vice-Chairman of B.O.D. Mothers Against Drunk Driving National. & B.O.D. Brain Injury Alliance. 20x year keynote at National Brain Injury Conferences. All honorariums donated to charities. Authored Spring Break: A True Story of Hope and Determination regarding a brain injured college student who received long-term inpatient, outpatient care and rehabilitation. Awarded: US Senate Official Proclamation, US Congressional Citation, U.S. House of Representatives Special Congressional Recognition, 20+ awards for legal and charitable accomplishments.

Traumatic Brain Injury

Deputy National Stroke Guide line in collaboration with Royal College Physician of UK • Prepared Stroke clinical Pathway currently used at Royal Hospital • Teacher and final MD and OMSB examiner • Speaker Sohar Second Medicine Symposium, 24/3/2013, • Speaker&Moderator 1st Kuwait North American Conference, April 2013 • OMSB Examiner 2013,2014 and up to date • Organizer &Speaker of Stroke Care Teaching Modules 1st/mar/2014 Sohar Hospital • Organizer &speaker: MS updates Sohar Hospital 2013, 2014 & Nov 20th / 2014 • Speaker & Organizer at 9GCC Neurology conference 6-8 /Nov/2014 • Contributors of the National diabetic guide line (prepared the diabetic neuropathy Module) • Chair Person & Speaker at the First Omani German Stroke Conference 21-22/Feb./2015 • Moderator 2nd Kuwait North American Conference, December 2014 • Chair Person Scientific Committee ,Organizer & Speaker 1st OMA 4-5/11/2015

Neurology, Medicine

Professor and head of department in Grant Medical College & Sir JJ Group of hospitals 1991-2002. Professor Emeritus - Grant Medical College & Sir JJ Group of Hospital September 2005 till date. National coordinator for World Federation of Neurology Education Continuum-CME programme since 2005. Member of the WHO International Advisory Group for the Revision of ICD 10, Diseases of the Nervous System in the area of Infections of the Nervous System - January 2010 Member - World Federation of Neurology Education Committee since 2010 till date. Chair - World Federation of Neurology Teaching Course Committee 2014.

Neurology

BUSINESS OWNER - MASTER KARATE INSTRUCTOR - SALES PROFESSIONAL - TEACHER Truly a Man of the World with a proven professional track record in business of increased sales, drastic volume growth and tremendous interpersonal, written and oral communication skills. Offers a strong record of performance maintaining relationships & exceeding sales plans. Sole Business Owner at Oasis Senior Advisors, a franchise in the Lehigh Valley of Pa. Proud Peace Corp Volunteer in Morocco, North Africa. Lived/ Trained Japanese Karate in Japan for SEVENTEEN YEARS. Currently teaching Japanese Karate Classes

Senior care, dementia care

Canadian dancer and fitness instructor, Jill Simpson, spent nearly a decade as caregiver to her father who had Lewy body dementia, a form most often associated with Parkinson’s disease. A decade later, returning to the world of dance, Jill was hired by the Alzheimer’s Society of Ontario to become as one of six Mind’s in Motion® physical activity leads in its ground breaking pilot program investigating the effects of exercise on early to mid-dementia. The more I learned, the more I kept thinking about my dad, and how this information might have helped him had I just known more about the most recent dementia research. The research led to the realization that as I dancer, as well as a fitness instructor, I was in a unique position to combine four of the most powerful activities for staving off cognitive decline: music, dance, aerobic activity, and cognitive challenge into a single program not only for those with early to mid dementia, but for a general population who simply want to keep their brains tuned up. The Body, Mind, and Movement Program™ for Brain Fitness is a unique combination of music and specific types of movement designed to stimulate blood flow to the brain, increase connectivity and communication between right and left hemispheres, and flood the brain with natural exercise-induced hormones that elevate mood and stimulate cognition. Jill has also recently trained and partnered with Dancing with Parkinson’s (DWP) Sarah Robichaud in Toronto to bring the DWP program to the Kitchener/Waterloo area. Although distinctly different, there is a great deal of overlap between the two programs as approximately 30% of those with Parkinson’s go on to develop a form of dementia, and finding alternate neural pathways is the goal of both programs.

Neurology

Born in 1968, he completed Medical Faculty University of Sarajevo 1997(MD degree). With IDU works since 1998 and since 1999 head of the ambulance to OST within the Mental Health Center Zenica. One of the founders of the Cantonal Institute for the disease of addiction Ze-Do Canton Zenica. In the period 2003-07 in the Cantonal Hospital Zenica and a University Clinical center in Sarajevo completed his residency in neurology and psychiatry. Medical Faculty in Sarajevo completed courses of good clinical practice and good experimental practices as well as postgraduate studies in clinical medicine(MSc degree). In the period 2013-15 ending sub-specialization in the field of addictology followed by planned training in the field of forensic psychiatry. Member of the expert group (2010-12) at the Department of Health of the Ministry of Civil Affairs, which has developed guidelines for the implementation of OST in B&H. UNODC internationally certified trainer in the field of substance abuse. The Cantonal Institute of addictions performed the following duties: a doctor in the clinic (2005-08), head of the hospital department (2008-12) a Head of all medical services and consultative addictologist. (2012-).Since 2013 employed as a forensic psychiatrist in Zenica and Busovaca prison and court expert in this field. Of the 2013 decision of the Minister of Health FB&H head of education in the field of addictology for employees Center for Mental Helath in FB&H.

Neurology

Advocate for the older population. Health Care Services for Older Adults through HOME VISITS. Older adults & family will be assisted in minimizing health risks through guidance and understanding of: -Personal responsibility for health status to maintain independence and control of health. -Health risk factors that occur with aging which can be modified to prevent complications and decrease risks. -Atypical responses to illnesses and treatment. -Education for compliance with medications and treatments as prescribed. -Improvement of nutrition, hydration, and activities for healthy lifestyle. -Approach to aging with the skill & enthusiasm required.

Aging, Nursing

Amy M. Clark, PhD is apart of the Dementia Care Ecosystem Project though UNMC and its partnership with the University of California - San Francisco. This project is funded by a 3-year, $10 million Healthcare Innovations Award from the Centers for Medicare & Medicaid. The impact of the Care Ecosystem will be studied, as it aims to support patients and their caregivers with decision-making, medications, caregiver support, online education, and, for a subset of patients, remote monitoring with smartphones, watches, and home sensors. Additionally Dr. Clark is a Visiting Professor with Nebraska Wesleyan University in the Social Work Department. Previously Amy served as the Dean of Health Professions at Nebraska Methodist College in Omaha, NE. In her role as Dean she oversaw 19 undergraduate, graduate and certificate on-ground and online programs in the health professions division. She was responsible for ensuring that the Allied Health Programs offered at NMC maintain their accreditation standards, enhance the student educational experience on campus and online through leadership of faculty and staff, strategic planning, curricular quality and efficiency, program integrity, and student satisfaction. Dr. Clark is a two-time Excellence in Teaching Award winner and has presented at local, state, and national conferences on a variety of topics related to teaching and research within the online and traditional on-ground educational settings.

neurology, dementia care

Born in Jammu-Tawi, India. After receiving Bachelor’s degree in Pharmaceutical Technology from the Birla Institute of Technology, Pilani, India, Rameshwar K. Sharma in 1960 entered the University of Connecticut for graduate work in Medicinal Chemistry and received his Ph.D. in 1963. Subsequently, after several Post-doctoral positions, including at the Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, he joined the University of Tennessee Medical Center at Memphis in 1970 where he rose to the rank of Full Tenured Professor of Biochemistry and Physiology. During this period through NIH Special Fellowship he spent two-years Sabbatical as a Visiting Professor at the McArdle Laboratory University of Wisconsin, Madison, in Dr. Henry Pitot’s lab, and subsequently additional two-years Sabbatical at the NIH, Bethesda in Dr. Michael Cashel’s lab. After Full Professorship at the Case Western University and Founder and Head of the Unit of Regulatory Biology at the Cleveland Clinic Foundation, Cleveland Ohio, he joined the University of Medicine and Dentistry at New Jersey as the Professor and Head of The Unit of Regulatory and Molecular Biology. Since July 2006 he is at the Salus University as a Distinguished Professor of Biochemistry and Molecular Biology. In a period spanning four decades, his research team has dedicated itself to the advancement of the field of membrane guanylate cyclase in the vertebrate systems. A few of its core findings that have impacted this and the field of cellular signal transduction follow. (1) With the discovery of the first membrane guanylate cyclase, ANF-RGC that was also the hormone receptor of ANF, the membrane guanylate cyclase surface receptor family was established. (2) It had a unique signal transduction mechanism. Instead of GTP in G-Protein signaling, it was regulated by ATP through its ARM module (ARM). The complete dissection of the module, followed through the concept-based analysis, localized a WTAPELL motif that controlled the entire signal transduction process, it was, then, predicted that this motif is the one that controls the ANF-RGC-dependent blood pressure in vasculature. This has now been proven true through the construction of the mouse genetic model. The mice lacking this motif are hypertensive. (3) The discovery and molecular characterization of the photoreceptor ROS-GC is a land mark event in the phototransduction field. It filled in the gap on the identity of the source of cyclic GMP that serves as a second messenger of the LIGHT signal; and made it possible to explain the principles of phototransduction in molecular and physiological terms. It also impacted the core membrane guanylate cyclase field by branching it into two: a transducer of both the hormone receptor and the intracellularly-generated Ca2+ signals. (4) ROS-GC field took additional direction when it was demonstrated that, besides phototransduction, it is biochemically linked with the transduction mechanisms of the inner segments of the retina, olfactory cilia and the olfactory bulb neurons. (5) The demonstration that ROS-GC is a Ca2+-bimodal switch, generated a new revolutionary concept where theoretically ROS-GC could be modulated through two different modes of Ca2+ signaling: via Ca2+-sensor GCAPS and S100B, the latter stimulating it and the mode found exclusively in cones and absent in rods. (6) Recently, an additional model of the photoreceptor ROS-GC1 has been disclosed. ROS-GC1 is responsive to the bicarbonate signal; it is not the pH effect, rather it binds to a specific motif of the ROS-GC and transduces the signal in generation of cyclic GMP. Preliminary findings suggest that this novel transduction system is present in a small number of mouse cones, and, importantly, is absent in the rods. This opens up a new area of sensory transduction mechanism, where it is meant to communicate with the external atmospheric carbon dioxide. The carbon dioxide is sensed through carbonic anhydrase, whose subtype has been detected in some cones, it converts CO2 to the bicarbonate, which, then, becomes the second messenger of CO2 and a signaling agent of ROS-GC1. Threaded through this past history and step-by-step gain in the field, This investigator feels fortunate that his group has made these important contributions in generating the field of membrane guanylate cyclase, establishing that cyclic GMP is an ubiquitous intracellular second messenger in prokaryotes and eukaryotes and that it plays a critical role in the control of physiological processes of cardiac vasculature, smooth muscle relaxation, blood volume, cellular growth, sensory transduction, neural plasticity, learning and memory. It is also gratifying to know that during this course he has been able to train and guide more than 35 doctoral and post-doctoral students, author 184 peer-reviewed research articles, including the editorship of three books, Special Editorship of two journals of Molecular and Cellular Biochemistry and the e-book editor of the Frontiers Molecular Neuroscience Research Topic, all focused on the field of membrane guanylate cyclases. At present I am on the editorial board of four international journals: Associate editor of the Frontiers in Molecular Neuroscience, Journal of Molecular and Cellular Biochemistry, Journal of Signal Transduction, Journal of Membrane Science & Technology. I am also the founding father and the President of the Guanylate Cyclase Innovative Biotechnology

Neuropharmacology

Kurt A Jellinger, born 1931 in Vienna, is Professor of Neurology and Neuropathology at the Medical University of Vienna (Vienna, Austria), was director of the Department of Neurology, Lainz Hospital in Vienna and since 2002, director of the Institute of Clinical Neurobiology (Vienna, Austria). He has been the recipient of numerous international grants and awards, is a member of numerous national and international scientific societies, editor of many international journals of neurology, neuroscience and neuropathology. His publication records exceeds 1,000 in perr-reviewed journals, 170 contributions in scientific book, inclduding several as editor, as well as 1.300 lectures at international meetings. For the last 50 years, his research included many fields of clinical neuropathology, neurochemistry and descriptive neurobiology.

His current research is focused on the neuropathology, molecular pathology and pathogenesis of movement disorders, neurodegenerative dementias, vascular cognitive disorders, late-life dementia and problems of cell death in CNS aging.

Anne cared for her husband at home until his younger onset Frontal Temporal Dementia required Residential Care. She still actively shares in his care. Prior to this she held National Senior Executive positions in large organisations, founded her own Management Consulting business and has been involved as a Director on many Statutory Boards & Government Advisory Committees. Her career commenced as a Registered Nurse in Operating Theatre Management, before moving into strategic corporate HR/Occupational Health & Safety Management. She is an active member of Alzheimer’s Australia (Vic) ‘Consumer Advisory Committee’, the Victorian Department of Health & Human Services – ‘ Public Sector Residential Aged Care - Reference Group’ & was appointed as Victorian representative to the ‘National Consumer Advisory Committee’ of Alzheimer’s Australia 2014 . She is a regular guest speaker, promoting greater understanding about the different forms & stages of Dementia including the Behavioural, Psychological & Communication changes that arise with the development & diagnosis of Dementia. She has held a Consumer Directed Home Care Package & has been involved in many Alzheimer' Australia (Vic) projects including ‘Driving & Dementia’, 'Intimacy & Dementia' & ‘Dementia Friendly Communities’.

Psychology, Behavioral Sciences

Panteleimon Giannakopoulos has completed his MD at age of 23 years from the University of Athens and is board certified psychiatrist and psychotherapist from 1999. He completed his postgraduate training in London and Paris before taking the chair of old age psychiatry in Geneva. He has also a full training in cognitive neurosciences focusing on dementing conditions. He was the chairman of the Department of Psychiatry in Geneva from 2005 to 2015 before being appointed as medical director of the Forensic Psychiatry for the Geneva county. He has published more than 220 peer-reviewed articles (h index: 42), and has been serving as an editorial board member and reviwer of repute.

Identification of markers of cognitive decline in mild cognitive impairment, late-onset depression and bipolar disorders, Cognitive impact of vascular lesions in brain aging, Alzheimer’s disease (AD), Use of recombinant clusterin to prevent ischemic damage in organotypic cultures and after middle cerebral artery occlusion

Marco Tulio Medina, born in the city of Tegucigalpa , MDC capital of the Republic of Honduras , on September 19, 1959, is a researcher in the fields of neurology and epilepsy, currently serves as Dean of the Faculty of Medical Sciences , UNAH . Founded in 1998, the Graduate Neurology at the UNAH with the support of the World Federation of Neurology (WFN), becoming a pilot program to developing countries, thus promoting education and neurological research in Honduras.

epilepsy genetic, neuro‐epidemiology and vascular endothelium

Doctor. Faculty of Medical Sciences, National University of Cuyo. Neurology residency. Private Community Hospital of Mar del Plata. Head of Residence, Residence of Neurology. Private Community Hospital of Mar del Plata. Doctor in medicine. Faculty of Medical Sciences, National University of Cuyo. Specialist in University Teaching. Faculty of Arts, National University of Cuyo.

Neurology, Neuropharmacology, Medical Sciences

As a post doctoral student, She is Interested in 1) Factors that enhance brain neuroplasticity, slowing the progression of neurodegenerative diseases; 2) Early surrogate biomarkers; 3) Development of new therapeutic strategies for patients with dementia; 4) Support therapies for relatives of patients with dementia and the effects of exercise and vascular risk factors in cognitive decline and dementia in the elderly.

dementia, vascular neurology, cognitive science

Dr. Soraya L. Valles completed her PhD in Alcohol action mechanisms with Consuelo Guerri her Director of Thesis (1996) from Instituto Investigationes Citologicas, in Valencia, Spain. Postdoctoral position in Sheffield, UK with Dr. Eva Qwarnstrom and Steve Dower. During 3.5 years, working in inflammation and IL-1R1 (from 1997 to 2000). Postdoctoral position in Spain, with Dr. Consuelo Guerri, working in alcohol and inflammation (from 2000 to 2004). Lecturer position in school of medicine, University of Valencia. Department of Physiology (from 2004 to 2008). Senior lecturer in the same University, (from 2008 to 2009). She is presently working as an Assistant professor in department of Physiology, school of medicine, University of Valencia.

Biochemistry, Genetics and Molecular Biology Neuroscience Medicine